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. 2017 Aug 14;7:8090. doi: 10.1038/s41598-017-08649-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of pitavastatin-zoledronic acid combinations on cell death. (A) Dead cells were measured by trypan blue staining after 72 and 96 hr of exposure to the indicated drug concentration. (B) Relative cell viability was measured by celltiter-Glo assay (ATP) after 72 hrs exposure to the indicated drug concentration. In both assays, the results (mean ± SD; n = 3) were compared to the effect expected for an additive interaction calculated using the Bliss independence criterion (solid line for each drug combination) and determined using the measured effect of the individual drugs in each individual experiment. Results were significantly different from the expected Bliss effect where shown (*P < 0.05; ** < 0.01; *** < 0.001, paired t-test).