Figure 5.

The effect of pitavastatin and pitavastatin-zoledronic acid on geranylgeranyl transferases. A2780, Skov-3 and Ovsaho cell lines were exposed to pitavastatin (1 µM, 5 µM and 1 µM, respectively) and zoledronic acid (10 µM) with and without geranylgeraniol (10 µM) and farnesol (10 µM) for 48 hrs. The levels of HMGCR, GGT-Iβ, GGT-IIβ and p53 were measured by immunoblotting of whole cell lysate. GAPDH was used as a loading control. The results are representative of 3 experiments.