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. 2017 Aug 14;7:8090. doi: 10.1038/s41598-017-08649-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of knockdown of GGT-Iβ and GGT-IIβ on sensitivity to pitavastatin. (A) Ovcar-4 cells exposed to 3 separate siRNA to GGT-Iβ and GGT-IIβ did not affect cell growth assessed by staining with SRB. (B) Ovcar-4 cells were transfected with the indicated siRNA and GGT-Iβ and GGT-IIβ measured by immunoblotting after 72 and 96 hrs. (C) Ovcar-4 cells were transfected with siRNA and after 24 hrs exposed to pitavastatin for a further 72 hrs before cell number was estimated by staining with SRB. The IC₅₀ of pitavastatin in combination with siRNA of GGT-Iβ and GGT-IIβ (mean ± SD, n = 3) was significantly different from cells transfected with non-targeting siRNA (NT#1) where shown (*P < 0.05, one-way ANOVA followed by Tukey’s post-hoc test).