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. 2017 Aug 14;7:8091. doi: 10.1038/s41598-017-08547-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of PT treatment combined with THA on tumor volume, body weight of nude mice, ERS pathways and apoptosis-associated proteins on PC9 tumor xenografts in vivo. (A) Photographs showing tumor xenograft morphologies in each group, changes in body weight of nude mice, and tumor growth curve drawn from the tumor volumes and treatment duration were provided. (B) Representative western blot results of the key proteins, including p-PERK, CHOP, Bcl2, Bax, Caspase 3, and p53 were shown. Membranes were re-probed for Tublin expression to show that similar amounts of protein were loaded in each lane. (C) Representative immunohistofluorescence staining images showed CHOP (red fluorescence) in the cell nucleus, Bax and Bcl2 (red fluorescence) in the cytoplasm, and DAPI (dark blue fluorescence) in the cell nucleus. The results were expressed as the mean ± SD; n = 6. ^aP < 0.05 vs. the control group, ^bP < 0.05 vs. the 50 mg/kg PT-treated group, ^cP < 0.05 vs. the 1 mg/kg THA-treated group.