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. 2017 Aug 14;7:8120. doi: 10.1038/s41598-017-08689-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SEA induces NLRP3 inflammasome activation in HSCs: (a) Western blot gels, (b) summarized data showing the expression of NLRP3, pro-caspase-1 and activated caspase-1 in HSCs after stimulation with SEA (50 μg/ml), full-length blots are included in the Supplementary Fig. S3, and (c) IL-1β production in cell supernatant; (d) Summarized relative mRNA levels of NLRP3 in HSCs in the presence or absence siNLRP3, as determined by RT-PCR. HSCs were incubated with or without SEA (50 μg/ml) for 2 h in the presence or absence siNLRP3; (e) Western blot gels, (f) summarized data showing the expression of NLRP3, pro-caspase-1, activated caspase-1 in HSCs, full-length blots are included in the Supplementary Fig. S4; (g) IL-1β production in cell supernatant. Scram: scrambled siRNA; siNLRP3: NLRP3 siRNA. Results are a representative of at least three independent experiments. ^*p < 0.05.