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. 2017 Aug 14;7:8120. doi: 10.1038/s41598-017-08689-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dectin-1 and JNK are involved in NLRP3 inflammasome activation: (a) western blot gels and (b) summarized data showing the expression of Syk, p-Syk (Y525/526), procaspase-1, activated caspase-1 and GAPDH in HSCs incubated with or without SEA (50 μg/ml) in the presence or absence anti-Dectin-1 antibody, full-length blots are included in the Supplementary Fig. S11, (c) IL-1β production in cell supernatant; (d) Western blot gels and (e) summarized data showing the expression of JNK, p-JNK (Thr 183 + Tyr 185), p38, p-p38 and GAPDH in HSCs after stimulation with SEA (50 μg/ml), full-length blots are included in the Supplementary Fig. S12; (f) Western blot gels and (g) summarized data showing the expression of JNK, p-JNK (Thr 183 + Tyr 185), procaspase-1, activated caspase-1 and GAPDH in HSCs incubated with or without SEA (50 μg/ml) for 2 h in the presence or absence inhibitors for JNK (SP600125) and p38 (SB 203580), full-length blots are included in the Supplementary Fig. S13, (h) IL-1β production in cell supernatant. Results are a representative of at least three independent experiments. ^*p < 0.05.