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. 2017 Aug 14;7:8087. doi: 10.1038/s41598-017-08079-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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New clues of the treatment of Alzheimer’s disease. Red hexagon denotes Alzheimer’s disease, yellow diamonds denote known drugs of Alzheimer’s disease, azure rectangles denote predicted new clues of treatment of Alzheimer’s disease. Green solid lines denote known DTIs, blue solid lines denote predicted DTIs, red separate arrow lines denote the associations between Alzheimer’s disease and known drugs, azure dash lines denote the associations between Alzheimer’s disease and new clues of treatment.