Table 1.
Overview of HLA associations with DILI
| Drug | HLA Allele | Type of study | Approximate odds ratio | Reference(s) |
|---|---|---|---|---|
| Amoxicillin-clavulanate | DRB1*15:01 | GWAS and candidate gene | 3 | |
| DQB1*06:02 | [22, 23, 28] | |||
| A*02:01 | 2.2 | |||
| B*18:01 | 4.0 | |||
| Flucloxacillin | B*57:01 | GWAS | 80 | [31, 32] |
| Minocycline | B*35:02 | GWAS | 29.6 | [40•] |
| Lumiracoxib | DRB1*15:01 | GWAS | 5 | [9] |
| DQB1*06:02 | ||||
| Lapatinib | DQA*02:01 | GWAS and candidate gene | 9 | [41] |
| Ximelagatran | DRB1*07:01 | GWAS | Not available (P = 6.0 × 10−6) | [43] |
| DQA1*02:01 | ||||
| Ticlopidine | A*33:03 | Candidate gene | 13 | [44] |
GWAS genome-wide association studies