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. 2017 Jun 27;595(16):5573–5586. doi: 10.1113/JP274344

Figure 5. Other CLCNKB mutations.

Figure 5

A, locations of the mutations (highlighted in magenta) in lateral view of the hClC‐Kb model (PDB ID: 3ORG). B, Western blot of wild‐type versus mutant hClC‐Kb channel in the absence (+EV) or presence (+Barttin) of barttin co‐expression. C, I–V relationship curves (upper graph) and current at holding potential of −145 mV (lower graph) of wild‐type (WT) and mutant hClC‐Kb channels with barttin co‐expression (mean ± SEM, n ≥ 6 for each). * P < 0.05 and ** P < 0.01 between wild‐type and each mutation by unpaired two‐tailed Student's t test.