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. 2017 Jun 27;595(16):5573–5586. doi: 10.1113/JP274344

Figure 7. The analysis of genotype–phenotype associations in patients with classic BS.

Figure 7

The remaining chloride conductance of mutant channels was plotted against phenotypic variables, including: A, age at diagnosis; B, urine calcium to creatinine ratio (Ca2+/Cr); C, plasma chloride (Cl−); D, plasma magnesium (Mg2+); E, plasma potassium (K+); and F, plasma bicarbonate (HCO3 −) concentrations. The r and P values of Spearman's test and the r 2 and P values of Pearson's test are shown. The CLCNKB mutations included for analysis were L81P, R92W, G164C, V170M, A242E, G246R, G296D, S297R, A349D, G424E, I447T and G470E. The phenotypes of the corresponding patients are listed in Table 1.