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Comparison of the substituted cathinones (methcathinone) to substituted amphetamines (methamphetamine) and the phenethylamine pharmacophore. The phenethylamine pharmacophore is bolded in each of the structures. Methamphetamine has a methyl (single carbon) off the α-carbon and nitrogen (N) terminus of phenethylamine. Methcathinone has carbonyl group (=O) off the β-carbon of methamphetamine.
