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. 2017 Aug 14;8:189. doi: 10.1186/s13287-017-0632-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Recovery of cartilage destruction by intra-articular injection of ESC-MSCs in a DMM model. a Flowchart of the in vivo experiment. b The Safranin O and Fast Green staining of cartilage destruction at 8 weeks after surgery. Boxed regions were magnified and shown in the next line. Scale bars, 200 μm. c OARSI scores of cartilage destruction. n = 10 in each group. d Immunohistochemical staining of COL II and ADAMTS5. Boxed regions show the gross view. Scale bars, 100 μm. COL II collagen type II, ESC-MSCs embryonic stem cell-derived mesenchymal stem cells, OARSI Osteoarthritis Research Society International