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. 2017 Aug 14;8:189. doi: 10.1186/s13287-017-0632-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effects of CM + Exo and CM-Exo on primary chondrocytes phenotype maintenance in the presence of IL-1β. a Expression of Col II (green) and ADAMTS5 (red) by primary chondrocytes treated with CM + Exo and CM-Exo. Scale bar, 40 μm. b Percentages of the Col II-positive cells with different treatments and immunofluorescence intensity of ADAMTS5 with different treatments. c Expression of Col II and ADAMTS5 by the primary chondrocytes with different treatments. COL II collagen type II, IL-1β, interleukin 1 beta