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. 2017 Aug 15;5:69. doi: 10.1186/s40425-017-0270-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Induction of Target-specific Immunity with Chimaeric VLP. The ability of each chimaeric VLP construct to induce an immune response specifically targeting their incorporated epitope was assessed using a modified in vivo cytotoxicity assay. a Modified in vivo cytotoxicity protocol, using a combination of CFSE and VPD staining to simultaneously monitor cytotoxicity against multiple target populations. Responses were assessed for T.VP60, S.VP60 and TS.VP60 in comparison to unmodified VP60 or synthetic peptides, calculating specific lysis of the b topIIα, c survivin and d topIIα/survivin target populations. Results are representative of three independent repeats. Statistical analysis performed using unpaired t-tests. NS = Non-significant, *** p < 0.001, **** p < 0.0001