Table 2.

ND modeling to assess the relative contribution of connectivity and gene expression profile in explaining tau progression and distribution

	Measure	Boluda DSAD (6 Mo)	Boluda CBD (6 Mo)	Iba Hipp. Inj. (6 Mo)	Iba Str. Inj. (6 Mo)	Clavaguera (15 Mo)
Mouse Model	/	P301S	P301S	P301S	P301S	Alz17
Infusate	/	DSAD Homogenate	CBD Homogenate	Synthetic Tau Fibrils	Synthetic Tau Fibrils	P301S Purified Tau
Seed Region	/	CA1 & V1	CA1	CA1 & CA3	Caudoput.	Hippocampus
ND USING STUDY SELECTED REGIONS (BIVARIATE CORRELATIONS)
Connectivity, Deposition	ΔR	0.30	0.22	0.45	0.23	0.25
Connectivity, Slope	ΔR	0.27	0.23	0.40	0.11	0.47
Spatial, Deposition	ΔR	0.01	0.00	0.01	0.00	0.03
Spatial, Slope	ΔR	0.02	0.00	0.01	0.00	0.01
General Gene, Dep.	ΔR	0.08	0.00	0.10	0.10	0.01
General Gene, Slope	ΔR	0.17	0.01	0.28	0.08	0.22
Specific Gene, Dep.	ΔR	0.01	0.02	0.03	0.02	0.00
Specific Gene, Slope	ΔR	0.02	0.02	0.22	0.00	0.05
Noradren. Gene, Dep.	ΔR	0.00	0.00	0.00	0.07	0.00
Noradren. Gene, Slope	ΔR	0.00	0.00	0.01	0.03	0.00
ND-CONNECTIVITY VS REGIONAL GENE EXPRESSION (MULTIVARIATE LINEAR MODEL)
Connectivity	T-Stat	12.74***	8.97***	10.51***	2.90**	2.50*
Seed or Baseline	T-Stat	−0.31	1.40	0.28	0.50	1.69
Summed Specific Gene Ex.	T-Stat	−1.85	−2.05*	−2.42*	2.53*	0.32
Summed Noradren. Gene Ex.	T-Stat	2.64**	1.67	1.92	0.44	0.19

The entries below the “Bivariate Correlations” row correspond to the ΔR obtained from running the ND model with each row’s network from reported seedpoint. The four entries after the “Multivariate Linear Model” row represent the t-values and p-value thresholds obtained from ND model predictions or summed regional expression predictions after they were input as independent predictors into a Multivariate Linear Fit Model. *** p < 0.001, ** p < 0.01, * p < 0.05