Table 3.
Regression and Linear Models analyses run restricted to only study selected regions and including all 426 ABA brain regions
| Measure | 4 Months Age | 6 Months Age | 8 Months Age | |
|---|---|---|---|---|
| ND MODELING (BIVARIATE CORRELATIONS) | ||||
| Analysis Using Study Selected Regions Only | ||||
| Connectivity | ΔR | 0.00 | 0.01 | 0.02 |
| Spatial | ΔR | 0.01 | 0.02 | 0.02 |
| General Gene | ΔR | 0.02 | 0.03 | 0.04 |
| Specific Tau Genes | ΔR | 0.08 | 0.13 | 0.12 |
| Noradrenergic Genes | ΔR | 0.05 | 0.10 | 0.10 |
| Analysis Using All 426 ABA Regions | ||||
| Connectivity | ΔR | 0.09 | 0.16 | 0.21 |
| Spatial | ΔR | 0.00 | 0.00 | 0.01 |
| General Gene | ΔR | 0.00 | 0.00 | 0.00 |
| Specific Gene | ΔR | 0.00 | 0.00 | 0.00 |
| Noradrenergic Gene | ΔR | 0.00 | 0.00 | 0.00 |
| ND VS REGIONAL GENE EX. (MULTIVARIATE LIN. MOD.) | End Timepoint Deposition | Analysis Using Study Selected Regions Left |
End Timepoint Deposition | |
| Connectivity | T-Stat | −0.20 | 6.92*** | |
| Baseline Deposition | T-Stat | 1.73 | ⇐ | 1.83 |
| Summed Specific Gene Ex. | T-Stat | 2.41* | Analysis Using All 426 ABA Regions Right |
1.65 |
| Summed Noradren. Gene Ex. | T-Stat | 1.05 | ⇒ | 3.96*** |
The entries under the “Bivariate Correlations” row correspond to the ΔR obtained from running the ND model from the baseline pathology measurement as this dataset [17] had no exogenous seedpoint. The four entries after the “Multivariate Linear Model” row represent the t-values and p-value thresholds obtained from ND model predictions or summed regional expression predictions after they were input as independent predictors into a Multivariate Linear Fit Model. Merged row (in the bivariate analyses section) and column separators (in the multivariate linear model section) denote which statistics correspond to analyses run restricted to only study selected regions or run using all 426 ABA brain regions. For T-Stats: *** p < 0.001, ** p < 0.01, * p < 0.05