Table 3.
GO analysis of leak/peri-exosomal proteins. A total of 699 high-confidence proteins appearing in the +4°C and −80°C storage supernatant were analysed for biological processes by GO-Slim (Panther database). Shown are the fold enrichment of the biological process and the significance (p-value, Bonferroni correction).
| PANTHER GO-Slim biological process | Enrichment | p-value |
|---|---|---|
| Gluconeogenesis (GO:0006094) | 10.99 | 5.44E-03 |
| Tricarboxylic acid cycle (GO:0006099) | 10.45 | 1.57E-03 |
| Glycolysis (GO:0006096) | 9.8 | 1.28E-04 |
| Fatty acid biosynthetic process (GO:0006633) | 6.3 | 1.53E-03 |
| Purine nucleobase metabolic process (GO:0006144) | 6.28 | 1.90E-04 |
| Protein complex assembly (GO:0006461) | 5.16 | 4.86E-07 |
| Protein complex biogenesis (GO:0070271) | 5.13 | 5.40E-07 |
| Blood coagulation (GO:0007596) | 4.62 | 9.15E-03 |
| Monosaccharide metabolic process (GO:0005996) | 4.2 | 1.01E-02 |
| Chromatin organization (GO:0006325) | 4.04 | 2.32E-07 |
| Macrophage activation (GO:0042116) | 3.96 | 3.51E-02 |
| Fatty acid metabolic process (GO:0006631) | 3.83 | 7.00E-05 |
| Translation (GO:0006412) | 3.64 | 1.18E-06 |
| Proteolysis (GO:0006508) | 3.59 | 1.14E-13 |
| Cellular component biogenesis (GO:0044085) | 3.45 | 2.17E-09 |
| Cellular amino acid metabolic process (GO:0006520) | 3.34 | 5.79E-04 |
| Generation of precursor metabolites and energy (GO:0006091) | 3.22 | 2.96E-03 |
| Catabolic process (GO:0009056) | 2.98 | 7.38E-11 |
| Lipid metabolic process (GO:0006629) | 2.78 | 1.97E-06 |
| Cellular component organization or biogenesis (GO:0071840) | 2.58 | 4.22E-18 |
| Cellular component organization (GO:0016043) | 2.45 | 4.05E-14 |
| Cellular component morphogenesis (GO:0032989) | 2.21 | 2.02E-02 |
| Organelle organization (GO:0006996) | 2.15 | 1.30E-03 |
| Protein metabolic process (GO:0019538) | 2.12 | 3.65E-12 |
| Immune system process (GO:0002376) | 1.79 | 3.12E-03 |
| Primary metabolic process (GO:0044238) | 1.69 | 2.39E-18 |
| Transport (GO:0006810) | 1.61 | 3.94E-03 |
| Metabolic process (GO:0008152) | 1.58 | 2.75E-16 |
| Localization (GO:0051179) | 1.55 | 9.11E-03 |
| Cellular process (GO:0009987) | 1.24 | 1.05E-03 |
| Multicellular organismal process (GO:0032501) | 0.58 | 2.03E-02 |
| Unclassified (UNCLASSIFIED) | 0.57 | 0.00E+00 |
| RNA metabolic process (GO:0016070) | 0.53 | 1.81E-02 |
| Developmental process (GO:0032502) | 0.5 | 7.71E-03 |
| Cell surface receptor signalling pathway (GO:0007166) | 0.42 | 4.02E-03 |
| Neurological system process (GO:0050877) | 0.34 | 4.45E-05 |
| Transcription from RNA polymerase II promoter (GO:0006366) | 0.27 | 2.92E-04 |
| Regulation of transcription from RNA polymerase II promoter (GO:0006357) | 0.25 | 3.13E-03 |
| Sensory perception (GO:0007600) | 0.25 | 7.18E-05 |
| G-protein coupled receptor signalling pathway (GO:0007186) | 0.25 | 1.22E-02 |
| Transcription, DNA-dependent (GO:0006351) | 0.21 | 3.82E-07 |