Fig. 1.

Gastric histology showing the protective effects of Citrus sinensis peel extract (CSPE), Hesperidin (H) and Omeprazole (OM) on EtOH-induced histological alteration in stomach. Animals were pre-treated with various doses of CSPE (100, 200 and 400 mg/kg, b.w., p.o.), OM (20 mg/kg, b.w., p.o.), Hesperidin (50 mg/kg, b.w., p.o) or bi-distilled water, challenged with a single oral administration of EtOH (4 g/kg, b.w., p.o.) or NaCl 9‰ for two hours. a: control; b: EtOH; c: EtOH+ CSPE-100; d: EtOH+ CSPE-200; e: EtOH+ CSPE-400 and f: EtOH+ H; g: EtOH+ OM). The data are expressed as mean ± S.E.M. (n = 10) *: p < 0.05 compared to the control group and #: p < 0.05 compared to the EtOH group