Fig. 3.

Subacute effect of Citrus sinensis peel extract (CSPE), Hesperidin (H) and Omeprazole (OM) on gene expression of COX-2 relative to β-actin in gastric mucosa of rats induced by ethanol (EtOH) in rats. Animals were pre-treated with various doses of CSPE (100, 200 and 400 mg/kg, b.w., p.o.), OM (20 mg/kg, b.w., p.o.), Hesperidin (50 mg/kg, b.w., p.o) or bi-distilled water, challenged with a single oral administration of EtOH (4 g/kg, b.w., p.o.) or NaCl 9‰ for two hours. The data are expressed as mean ± S.E.M. (n = 10)*: p < 0.05 compared to the control group and #: p < 0.05 compared to the EtOH group