Table 2.
Effect of Citrus sinensis peel extract (CSPE), Omeprazole (OM) and Hesperidin (H) on gastric macroscopic alterations induced by EtOH: ulcer index and Percentage of protection (%). Animals were pretreated with various doses of CSPE (100, 200 and 400 mg/kg, p.o.), OM (20 mg/kg, b.w., p.o.), H (50 mg/kg, p.o)
| Pre-traitement | Stomach | |
|---|---|---|
| Ulcer area (mm2) (Mean ± S.E.M) |
Percentage of protection (%) | |
| Control | 0 | -- |
| EtOH | 98.50 ± 3.59* | -- |
| EtOH + CSPE-100 | 71.60 ± 1.9** | 27.26% |
| EtOH + CSPE-200 | 47.60 ± 1.88** | 53.19% |
| EtOH + CSPE-400 | 11.20 ± 0.86** | 89.80% |
| EtOH + Omeprazole | 21.34 ± 1.72** | 78.16% |
| EtOH + Hesperidin | 26.42 ± 1.74** | 73.60% |
The data are expressed as mean ± S.E.M. (n = 10) * p < 0.05 compared to control group and ** p < 0.05 compared to EtOH group