Table 2.

Multivariable Adjusted Association of PFOA with Diabetes, by Diabetes Type

	Type 1 diabetes	Type 2 diabetes	Uncategorized*
	OR (95% CI)	OR (95% CI)	OR (95% CI)
PFOA
PFOA, ng/mL**	0.76 (0.71–0.80)	0.94 (0.92–0.97)	0.94 (0.90–0.99)
Age, years	1.03 (1.03–1.04)	1.07 (1.07–1.08)	1.05 (1.04–1.05)
Sex, female	0.48 (0.41–0.57)	0.60 (0.56–0.65)	0.80 (0.70–0.92)
BMI, kg/m2	1.10 (1.08–1.11)	1.13 (1.13–1.14)	1.10 (1.09–1.11)
eGFR, mL/min/1.73m2**
90–119	Ref	Ref	Ref
≥120	1.21 (0.77–1.89)	0.76 (0.55–1.07)	1.39 (0.97–1.99)
60–89	0.85 (0.70–1.03)	0.69 (0.63–0.75)	0.72 (0.63–0.82)
<60	2.40 (1.86–3.10)	0.75 (0.66–0.85)	0.63 (0.50–0.79)
Hemoglobin, g/dL	0.77 (0.73–0.82)	0.84 (0.81–0.87)	1.27 (1.20–1.34)
Iron, µ/dL**	0.82 (0.68–1.00)	0.93 (0.84–1.02)	0.82 (0.70–0.97)
PFOS
	OR (95% CI)	OR (95% CI)	OR (95% CI)
PFOS, ng/mL**	0.73 (0.67–0.79)	0.92 (0.88–0.96)	0.95 (0.88–1.03)
Age, years	1.03 (1.03–1.04)	1.07 (1.07–1.08)	1.05 (1.04–1.05)
Sex, female	0.49 (0.41–0.57)	0.60 (0.56–0.65)	0.81 (0.70–0.93)
BMI, kg/m2	1.10 (1.09–1.11)	1.13 (1.13–1.14)	1.10 (1.09–1.11)
eGFR, mL/min/1.73m2**
90–119	Ref	Ref	Ref
≥120	1.30 (0.94–1.81)	0.69 (0.52–0.92)	1.08 (0.79–147)
60–89	0.84 (0.70–1.03)	0.69 (0.63–0.75)	0.72 (0.63–0.82)
<60	2.47 (1.92–3.17)	0.75 (0.66–0.85)	0.63 (0.50–0.79)
Hemoglobin g/dL	0.79 (0.74–0.84)	0.84 (0.82–0.87)	1.26 (1.19–1.33)
Iron, µ/dL**	0.85 (0.70–1.03)	0.92 (0.84–1.02)	0.80 (0.68–0.94)

^*Diabetes type not reported, reported as not known, or based on blood glucose at study entry

^**Natural logarithmically transformed before analysis