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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2017 Jun;69(6):335–342. doi: 10.1097/FJC.0000000000000465

Figure 2. Poldip2 signal transduction pathways.

Figure 2

Poldip2 by itself or via interaction with its binding partners is involved in multiple signaling pathways, modulating focal adhesion turnover, ECM regulation, cell migration, proliferation and differentiation, renal sensory-nerve activation, DNA replication and damage repair, mitochondrial function and morphology and autophagy. Those processes contribute to vascular stiffness, collateral formation, myocardium remodeling, the diuretic/natriuretic response, BBB permeability and retinal degeneration. BBB, blood-brain-barrier; PCNA, proliferating cell nuclear antigen; MMPs, matrix metalloproteinases.