Table 1.
Poldip2 binding partners Poldip2 binding partners reported in the literature. “Untested” indicates that the putative function has not been tested experimentally.
| Poldip2 binding protein | Putative function | Reference |
|---|---|---|
| Polymerase δ p50 subunit | DNA replication and damage repair | 1 |
| Proliferating cell nuclear antigen | DNA replication and damage repair | 1 |
| Polymerase η | DNA damage response | 22 |
| Rev1 polymerase | DNA damage response | 22 |
| Rev7 | DNA damage response | 22 |
| Polymerase λ | DNA damage response | 17 |
| PrimPol | DNA damage response | 21 |
| HPV 16 E7 | Viral DNA replication | 13 |
| p22phox | Reactive oxygen species production, cytoskeletal remodeling and cell migration; Modulation of transient receptor potential vanilloid 1 channel activity | 3,5 |
| CEACAM1 | Translocation from membrane to nucleus | 12 |
| Transcription factor A | mtDNA metabolism (untested) | 14 |
| Mitochondrial single stranded DNA binding protein 1 (mtSSB) | mtDNA metabolism (untested) | 14 |
| Leucine-rich protein (LPRC) | mtDNA metabolism (untested) | 14 |
| Lon protease homolog (LONM) | mtDNA metabolism (untested) | 14 |
| Heat shock protein 90-beta (HSP90β) | mtDNA metabolism (untested) | 14 |
| Heat shock protein 70 (HSP70) | mtDNA metabolism (untested) | 14 |
| ATP-dependent Clp protease (CLPX) | mtDNA metabolism (untested) | 14 |
| Heat shock protein 60 (HSP60) | mtDNA metabolism (untested) | 14 |
| ATP synthase beta chain (ATPB) | mtDNA metabolism (untested) | 14 |
| Squamous cell carcinoma antigen 1 (SCC1) | mtDNA metabolism (untested) | 14 |
| Squamous cell carcinoma antigen 2 (SCC2) | mtDNA metabolism (untested) | 14 |
| Aspartate aminotransferase (AATM) | mtDNA metabolism (untested) | 14 |
| Malate dehydrogenase (MDH) | mtDNA metabolism (untested) | 14 |
| 2,4-dienoyl-CoA reductase | mtDNA metabolism (untested) | 14 |
| Peroxiredoxin 3 (PDX3) | mtDNA metabolism (untested) | 14 |
| ATP synthase | mtDNA metabolism (untested) | 14 |
| Selenium binding protein 1 (SELENBP1) | Tumor suppressor (untested) | 47,48 |
| MAP3K7IP1 | TGFβ receptor and TAK1 signaling mediator (untested) | 47 |
| Histone deacetylase 6 (HDAC6) | Cancer metastasis (untested) | 47 |
| 3-Phosphoinositide Dependent Protein Kinase 1 (PDPK1) | Cancer metastasis (untested) | 47 |
| Activating signal cointegrator 1 complex subunit 2 (ASCC2) | Activation by multiple transcription factors (untested) | 47,48 |
| Carboxypeptidase E (CPE) | Biosynthesis of peptide hormones and neuropeptides (untested) | 48 |
| 5′-aminolevulinate synthase 1 (ALAS1) | Mitochondrial metabolism (untested) | 48 |
| ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 (ATP5A1) | ATP synthesis (untested) | 49 |
| chromosome 15 open reading frame 48 (C15orf48) | Carcinogenesis (untested) | 49 |