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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Biomaterials. 2017 Jun 29;141:125–135. doi: 10.1016/j.biomaterials.2017.06.039

Figure 5.

Figure 5

MDA-MB-231 cells require fibrous collagen for invasion. (A) MDA-MB-231 spheroids were imaged 72 hours after encapsulation. Scale bar = 100 μm. (B) The presence of collagen was necessary for cell invasion, but invasion was not influenced by further increases in collagen concentration. ^ indicates p<0.01 to 0 mg/mL collagen of same stiffness. n=6–9, (C) In the presence of collagen, increasing stiffness was accompanied by decreased invasion. ^ indicates p<0.01 when compared to 2 kPa of same collagen concentration. n=6–9. Data are presented as box and whisker plots representing the median with the 1st and 3rd quartiles (box) plus the range (whiskers).