Table 2.
Comparison of clinical characteristics between three different pathological CMT1A subtypes.
| Subtype 1 | Subtype 2 | Subtype 3 | |
|---|---|---|---|
| Number of patients | 3 | 10 | 11 |
| Age at onset (years) | 19.7 ± 11.9 | 21.5 ± 12.1 | 23.5 ± 17.8※ |
| Age at examination (years) | 25.0 ± 14.0 | 30.6 ± 12.7 | 29.7 ± 16.3※ |
| Disease duration (years) | 5.3 ± 4.0 | 9.2 ± 8.4 | 6.0 ± 5.0※ |
| Distal muscle weakness | |||
| Upper limbs | 4.7 ± 0.6 | 4.2 ± 0.6 | 4.5 ± 0.7※ |
| Lower limbs | 3.7 ± 2.3 | 3.5 ± 0.8 | 3.4 ± 1.3※ |
| Muscle atrophy | |||
| Hand | 2 (66.7%) | 7 (70%) | 4 (36.4%)※ |
| Calf | 2 (66.7%) | 4 (40%) | 4 (36.4%)※ |
| Sensory loss | 3 (100%) | 6 (60%) | 6 (54.5%)※ |
| Areflexia | 3 (100%) | 8 (80%) | 11 (100%)※ |
| Foot deformity | 1 (33.3%) | 5 (50%) | 7 (63.6%)※ |
Subtype 1: pure onion bulb formation; Subtype 2: onion bulb formation with axonal sprouts; Subtype 3: focally thickened myelin with onion bulb formation or/and axonal sprouts. ※P > 0.05.