TABLE 2.

Results of surveys of site clinical research associates (N=70) and patients (N=63)

a. Effort by site clinical research associates
Activity	Median	Mean	Range
Time for CRA to learn PRO-CTCAE software	60 min	70 min	30–240*
Time for CRA to teach PRO-CTCAE to one patient	10 min	16 min	2–60
Time per clinic visit for PRO-CTCAE administrative tasks	10 min	12 min	0–60
Time spent with each patient at clinic visits for PRO- CTCAE	15 min	17 min	0–60

b. Ease of use by site clinical research associates
After training, PRO-CTCAE software was:
- Easy to use	52/66 (79%)
- Moderate to use	13/66 (20%)
- Difficult to use	1/66 (2%)
Did you experience any of these obstacles to implementing PRO- CTCAE at your site:
- No obstacles	46/64 (72%)
- Staff resources inadequate	8/64 (13%)
- Patient resistance	12/64 (19%)
- Staff resistance	2/64 (3%)

c. Technical difficulties experienced by site clinical research associates
Proportion of CRAs who noted experiencing more than minimal technical difficulties	23/55 (35%)
Number of CRAs reporting any problems (non-mutually exclusive) with:
- Connectivity/network problems/slow	17/55 (31%)
- Lost passwords	8/55 (15%)
- Software errors	6/55 (11%)
- Other (firewall, hardware, screen problem)	5/55 (10%)

d. Patient impressions
	Agree	Disagree
PRO-CTCAE questions were easy to understand	55/60 (92%)	5/60 (8%)
PRO-CTCAE software was easy to use	51/60 (85%)	9/60 (15%)
PRO-CTCAE improved discussions with my doctor/nurse	45/59 (76%)	14/59 (24%)
I would recommend PRO-CTCAE to other patients	45/59 (76%)	14/59 (24%)
PRO-CTCAE made me feel more in control of my own care	40/58 (69%)	18/58 (31%)

Abbreviation: CRA, Clinical Research Assistant at individual study sites

^*1 CRA noted 240 min; 8 CRAs 120 min; all others <90 min

Abbreviation: CRA, Clinical Research Assistant at individual study sites