Skip to main content
. Author manuscript; available in PMC: 2018 Jan 27.
Published in final edited form as: Science. 2017 Jan 27;355(6323):395–398. doi: 10.1126/science.aai8128

Fig. 2. Activating Fc phenotype in dengue infection correlates with disease severity.

Fig. 2

(A) Increased afucFc on anti-ENV or anti-HA IgG correlated with DHF/DSS (DHF). (B) Stronger correlations yet were observed when patients were stratified based on thrombocytopenia (TH+) (platelets <100,000/ul) during hospitalization. TH+ patients had elevated abundance of afucFc on anti-ENV or anti-HA IgG compared with TH− patients. (C) TH+ patient anti-ENV IgGs were skewed in distribution toward the IgG1 subclass, while anti-HA IgGs from TH+ patients were not. (D,E) Patients with the lowest recorded platelet count during hospitalization had the greatest abundance of afucFc and the highest IgG1/IgG2 ratio of anti-ENV IgGs. (F) Abundance of afucFc on anti-ENV IgG correlated with IgG1/IgG2 distribution; elevated afucFc and IgG1/IgG2 correlated with the severity of thrombocytopenia. The single patient with DSS in the cohort had the greatest abundance of afucFc and the highest IgG1/IgG2 ratio (marked with *). (G,H) Elevated hematocrit (HCT), a marker of plasma leak that distinguishes DHF/DSS from DF, correlated with anti-ENV IgGs having the greatest abundance of afucFc and the highest IgG1/IgG2 ratio.