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. Author manuscript; available in PMC: 2018 Jan 27.
Published in final edited form as: Science. 2017 Jan 27;355(6323):395–398. doi: 10.1126/science.aai8128

Fig. 3. DHF IgG induces FcR-dependent platelet drop in vivo.

Fig. 3

(A) IgG from TH+ patients, but not IVIG, caused a drop in platelets that was dependent on presence of the Fc glycan (TH+agly) and FcRs (α−/−). (B) Platelet drop was dependent on expression of FcgRIIA (CD32A) and FcgRIIIA (CD16A). (C) TH+ or TH− IgG or IVIG was incubated with human platelets. IgG at equivalent concentrations eluted from platelets, or the remaining supernatant (sup), reacted with DENV NS1 protein but not DENV ENV protein. Data are representative of experiment performed in duplicate. (D) NS1-specific IgG from TH+ patients had elevated afucFc glycoforms over anti-HA IgG from patients with day 7 IAV (HA).

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