Table 1.
Characteristics of nonsarcopenia group vs sarcopenia group in each OAD phenotypes
| Characteristics | Asthma
|
COPD
|
ACOS
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Nonsarcopenia (n=76) |
Sarcopenia (n=13) |
P-value | Nonsarcopenia (n=497) |
Sarcopenia (n=251) |
P-value | Nonsarcopenia (n=75) |
Sarcopenia (n=35) |
P-value | |
| Age (years) | 61.28±7.39 | 62.23±9.07 | 0.678 | 65.05±7.64 | 67.41±8.32 | <0.001 | 66±7.6 | 67.06±6.73 | 0.483 |
| Female (%) | 81.6% | 69.2% | 0.289 | 25.2% | 19.1% | 0.065 | 42.7% | 34.3% | 0.403 |
| Height (m) | 1.56±0.08 | 1.56±0.07 | 0.596 | 1.64±0.09 | 1.63±0.08 | 0.295 | 1.60±9.23 | 1.60±7.65 | 0.948 |
| Weight (kg) | 61.94±8.53 | 53.88±8.76 | 0.002 | 65.74±9.73 | 56.87±8.18 | <0.001 | 63.67±9.73 | 55.65±8.23 | <0.001 |
| BMI (kg/m2) | 25.33±2.3 | 21.65±2.22 | <0.001 | 24.48±2.51 | 21.37±2.26 | <0.001 | 24.78±2.57 | 21.64±2.37 | <0.001 |
| SMI (kg/m2) | 16.1±1.91 | 14.1±1.76 | 0.001 | 17.21±1.7 | 15.02±1.35 | <0.001 | 16.84±1.79 | 14.73±1.54 | <0.001 |
| ASMI (kg/m2) | 6.6±1.08 | 5.42±0.7 | <0.001 | 7.32±0.91 | 6.21±0.71 | <0.001 | 7.08±1 | 5.99±0.8 | <0.001 |
| FMI (kg/m2) | 8.20±1.9 | 6.46±1.62 | 0.002 | 6.19±2.11 | 5.36±1.94 | <0.001 | 6.95±2.68 | 5.98±2.06 | 0.062 |
| AFMI (kg/m2) | 3.37±0.88 | 2.62±0.73 | 0.005 | 2.38±0.92 | 2.07±0.85 | <0.001 | 2.74±1.23 | 2.39±0.95 | 0.136 |
| Smoking (pack years) | 2.62±7.95 | 3.42±7.05 | 0.735 | 21.77±22.56 | 25.26±24.04 | 0.051 | 18.46±21.08 | 26.29±22.42 | 0.078 |
| EQ-5D index | 0.86±0.171 | 0.83±0.297 | 0.584 | 0.92±0.146 | 0.9±0.152 | 0.035 | 0.85±0.17 | 0.84±0.18 | 0.818 |
| EQ-VAS | 72.20±17.569 | 68.86±21.23 | 0.598 | 74.52±18.18 | 75.28±61.31 | 0.798 | 66.85±22.87 | 60.77±17.66 | 0.167 |
| Physical inactivity n (%) | 0.348 | 0.001 | 0.036 | ||||||
| Yes | 22 (28.9%) | 2 (15.4%) | 87 (17.5%) | 69 (27.5%) | 24 (32%) | 19 (54.3%) | |||
| No | 54 (71.1%) | 11 (84.6%) | 409 (82.3%) | 181 (82.1%) | 51 (68%) | 16 (45.7%) | |||
| Unknown | 0 | 0 | 1 (0.2%) | 1 (0.4%) | 0 | 0 | |||
| FEV1 (L) | 2.4±0.52 | 2.48±0.6 | 0.617 | 2.35±0.63 | 2.17±0.62 | ,0.001 | 1.85±0.62 | 1.56±0.54 | 0.017 |
| FEV1 (%) | 77.97±4.42 | 76.64±4.73 | 0.96 | 80.09±14.31 | 76.43±16.4 | 0.002 | 69.37±17.43 | 57.79±16.13 | 0.001 |
| FVC (L) | 3.08±0.69 | 3.24±0.79 | 0.462 | 3.65±0.9 | 3.46±0.84 | 0.007 | 3.12±0.91 | 2.83±0.73 | 0.101 |
| FVC (%) | 94.35±8.78 | 96.5±9.23 | 0.419 | 91.05±14.07 | 88.9±14.85 | 0.053 | 85.1±16.07 | 77.56±13.97 | 0.019 |
| FEV1/FVC | 0.78±0.04 | 0.77±0.04 | 0.325 | 0.64±0.06 | 0.62±0.07 | <0.001 | 0.6±0.09 | 0.55±0.11 | 0.018 |
| ALP (IU/L) | 237.13±69.36 | 247.15±60.61 | 0.626 | 245.56±75.71 | 255.82±76.69 | 0.082 | 240.68±70.72 | 277.6±85.54 | 0.019 |
| PTH (pg/mL) | 65.11±24.28 | 62.02±18.94 | 0.664 | 66.05±25.48 | 67.57±29.4 | 0.463 | 67.15±23.29 | 72.5±29.16 | 0.303 |
| Vitamin D (ng/mL) | 18.41±5.81 | 20.66±6.6 | 0.211 | 21.12±7.14 | 21.29±8.38 | 0.782 | 19.68±6.76 | 20.62±8.08 | 0.525 |
| Femur T-score | −0.25±0.97 | −0.51±1.3 | 0.403 | −0.14±0.97 | −0.7±0.89 | <0.001 | −0.43±0.94 | −1±0.78 | 0.001 |
| Femur neck T-score | −1.32±1.02 | −1.4±1.46 | 0.866 | −0.93±1.04 | −1.4±0.99 | <0.001 | −1.38±1.08 | −1.76±0.87 | 0.071 |
| Lumbar T-score | −1.35±1.25 | −0.8±1.68 | 0.168 | −0.78±1.38 | −1.31±1.36 | <0.001 | −1.2±1.32 | −1.89±1.24 | 0.011 |
Note: Data presented as mean ± standard deviation unless stated otherwise.
Abbreviations: OAD, obstructive airway disease; COPD, chronic obstructive pulmonary disease; ACOS, asthma–COPD overlap syndrome; BMI, body-mass index; SMI, skeletal muscle index; ASMI, appendicular SMI; FMI, fat-mass index; AFMI, appendicular FMI; EQ-5D, EuroQol five-dimensional; EQ-VAS, EuroQol visual analogue scale; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; ALP, alkaline phosphatase; PTH, parathyroid hormone.