Table 1. Parameter values used for TCR internalization mathematical modeling.

Description	Estimate
Initial number of TCR	30 × 103
Diffusion constants of TCR and pMHC, cm2·s−1	3 × 10−10
On-rate of pMHC, cm2·s−1	1 × 10−10
Kinetic proofreading steps	6
Kinetic proofreading rate, s−1	0.25
Down-regulation rate for triggered, unbound TCR, s−1	3 × 10−3
Surface area of cells, cm2	5 × 10−6
Radius of contact region, cm	4.7 × 10−4

Parameter values were assigned according to ref. 20.