Table 1.
Clinical signs, gross findings, histopathologic lesions, and microbiologic findings of 48 TRP1/TCR and 3 reporter-strain mice submitted for gross or complete necropsy
| Clinical signs at initial observation |
Gross lesions |
Histopathologic lesions |
|||||||||||||
| Sex | Age at necropsy (d) | Unkempt fur, pruritus | UD | Ocular lesiona | Hunched posture | Otherb | Sup purative infectionc | Otherd | Dermatitis, folliculitis | Suppurative infection | Lymphoid depletion | Myeloid hyper plasia | Othere | Microbiologic resultsf | |
| Parental strain | |||||||||||||||
| 1 | F | 133 | + | – | + | + | – | + | + | – | + | + | + | + | NP |
| 2 | F | NA | + | – | + | – | – | + | + | + | + | + | + | + | Pp |
| 3 | F | 322 | + | – | + | + | – | + | + | + | + | – | + | – | None |
| 4 | F | NA | – | – | – | + | + | + | + | – | + | + | + | + | Pp |
| 5 | F | 773 | + | – | – | + | + | – | + | + | + | + | + | + | NP |
| 6 | F | 351 | + | – | + | + | + | + | + | + | + | + | – | + | Pp, Cb |
| 7 | F | 113 | + | – | + | + | – | + | – | NP | Pp | ||||
| 8 | F | NA | + | – | + | + | – | + | – | NP | Pp | ||||
| 9 | M | 241 | + | + | – | – | – | – | – | NP | NP | ||||
| 10 | F | 260 | + | + | – | – | – | – | – | NP | NP | ||||
| 11 | F | 249 | + | + | – | + | + | – | + | NP | NP | ||||
| 12 | M | 291 | – | – | – | – | + | – | – | NP | NP | ||||
| 13 | F | 167 | + | + | – | – | – | – | – | NP | NP | ||||
| 14 | M | 106 | – | – | – | – | – | + | – | NP | NP | ||||
| 15 | F | 388 | + | + | – | + | – | – | – | NP | NP | ||||
| 16 | F | 120 | + | – | + | + | – | + | – | NP | NP | ||||
| 17 | M | 130 | + | – | + | – | + | + | – | NP | NP | ||||
| 18 | M | 852 | + | + | – | – | – | – | – | NP | NP | ||||
| 19 | M | 56 | + | – | + | + | + | + | + | NP | NP | ||||
| 20 | F | 85 | + | – | + | – | + | + | – | NP | NP | ||||
| 21 | F | 496 | + | + | – | + | + | + | + | NP | NP | ||||
| 22 | F | 91 | + | + | – | – | + | + | + | NP | NP | ||||
| 23 | M | 149 | + | – | + | + | + | – | – | NP | NP | ||||
| 24 | M | 149 | + | – | – | – | – | – | – | NP | NP | ||||
| 25 | M | 149 | + | – | – | – | – | – | + | NP | NP | ||||
| 26 | M | 85 | + | – | – | – | – | – | – | NP | NP | ||||
| 27–48 | 12M 10F | 85 (67–149) | – | – | – | – | – | – | – | NP | NP | ||||
| Reporter strains | |||||||||||||||
| 1 | M | 522 | + | + | – | – | + | – | + | NP | Cb | ||||
| 2 | F | 285 | + | + | – | – | – | – | + | + | + | + | + | + | Cb |
| 3 | F | 285 | + | + | – | – | – | – | – | + | + | + | + | + | Cb |
Cb, Corynebacterium bovis; F, female; M, male; NA, not available; NP, not performed; Pp, Pasteurella pneumotropica; UD, ulcerative dermatitis
Includes retroorbital abscesses, corneal abrasion, and corneal ulceration
Includes scaling dermatitis, poor body condition, skin pallor, soft stool, and rectal prolapse
Includes retroorbital abscess; otitis media or interna; mastitis; pyometra; or abscesses in lymph nodes, clitoral glands, or preputial glands
Includes pregnancy, hemoabdomen, mass effects, splenomegaly, lymphadenopathy, tissue cysts (renal, adrenal, or salivary gland), edema or tissue ulceration
Includes extramedullary hematopoiesis; gastrointestinal inflammation and necrosis (colitis); neutrophilic periodontitis with intralesional hair shafts; renal interstitial fibrosis and mineralization; hydronephrosis; ovarian atrophy; neoplasia; periportal hepatitis
Samples from suppurative exudates and skin were submitted for aerobic culture