Figure 1.

Historical diabetes data for mice in the SFB-contaminated room. NOD/ShiLtDvs mice that serve as putative disease-susceptible groups in ongoing experiments received weekly intraperitoneal injections of an IgG1 isotype-control antibody prior to SFB (2013, n = 41) and during SFB contamination (2014, n = 21). T1D incidence curves show a significant decrease (P = 0.0185, Mantel–Cox log-rank test) in incidence from approximately 60% to 30% by 30 wk of age. These mice were positive controls for ongoing antibody-based therapy studies and received an irrelevant IgG1 isotype control antibody that does not alter T1D development.