Figure 8.

Contact matrices (heat maps) between two rhodopsin helices, showing specific interactions between TM1 (helix 1) and TM2 (helix 2) (a) and between TM4 (helix 1) and TM5 (helix 2) (b). Results shown are the average for each ensemble. The color scale is as indicated in Figure 6. Circles indicate areas with key interhelical contacts. The identified amino acid interactions are numbered as follows: (1) F127^1.47 with L218^2.44; (2) L122^1.42 with L220^2.46, I123^1.43 with L218^2.44, and N219^2.45 with L220^2.46; (3) Y118^1.38 with D224^2.50, M119^1.39 with D224^2.50, F120^1.40 with D224^2.50, and F120^1.40 with L225^2.51; (4) F418^4.48 with L521^5.51 and T419^4.49 with L521^5.51; (5) F418^4.48 with F525^5.55; (6) M414^4.44 with F525^5.55, G415^4.45 with F525^5.55, and V416^4.46 with F525^5.55; (7) H411^4.41 with Y528^5.58, H411^4.41 with G529^5.59, and H411^4.41 with Q530^5.60.