. 2017 Apr 6;13(5):2254–2270. doi: 10.1021/acs.jctc.6b01246

Table 2. Sequences of the A_2AR Helices Used in Ensemble Simulation Sets.

A_2AR helices	sequence^a
TM2-wild-type	FVVSLAAAD52^2.50IAVGVLAIPFAITI
TM5-wild-type	MNYMVYFNFFACVLVP189^5.50LLLMLGVYLRI
TM5-M177^5.38A	MNYAVYFNFFACVLVP189^5.50LLLMLGVYLRI
TM5-M193^5.54A	MNYMVYFNFFACVLVP189^5.50LLLALGVYLRI
TM5-M193^5.54I	MNYMVYFNFFACVLVP189^5.50LLLILGVYLRI

Residues suggested to play a key role in the dimerization of the A_2AR TM5 helix²⁷ are indicated in bold; mutated residues are underlined and italicized. The conserved amino acid for each TM helix is italicized and is numbered using both the Ballesteros and Weinstein nomenclature (superscript) and by residue number.

Table 2. Sequences of the A2AR Helices Used in Ensemble Simulation Sets.

Table 2. Sequences of the A_2AR Helices Used in Ensemble Simulation Sets.