Table 2.
Failure Sites for non-type A Failures
| Patient | Local vs Regional | Predominant Failure Type | Primary Tumor Site | Pathologic TN Stage | Surgical margins | Neck dissection status and laterality | ECE | Neck Irradiation Laterality | DOI | PNI | LVI | Chemotherapy | CTV1 Dose (Gy/n. of Fracions) | Failure Site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | L | B (peripheral high dose) | gingiva | T2 N0 | -ve | -ve Ipsilat | -ve | Ipsilat | ≤1.5 cm | +ve | -ve | No | 60/30 | Ipsilat RMT&Maxilla |
| 2 | L | B (peripheral high dose) | FOM | T1N2c | -ve | +ve Bilat | +ve | Bilat | >1.5 cm | -ve | -ve | No | 13/6b | FOM |
| 3 | L | C (central int. dose) | RMT | yT4ayN0 | -ve | -ve Ipsilat | -ve | Bilat | ≤1.5 cm | -ve | U/S | I + C | 60/30 | Ipsilat Masticator Space |
| 4 | L | C (central int. dose) | tongue | T4aN2b | -ve | +ve Bilat | -ve | Bilat | >1.5 cm | -ve | -ve | No | 60/30 | FOM |
| 5 | L | C (central int. dose) | FOM | T4aN1 | -ve | +ve Bilat | -ve | Bilat | >1.5 cm | -ve | -ve | No | 60/30 | BOT |
| 6 | L | Aa | RMT | T4aN1 | +ve | +ve Ipsilat | -ve | Ipsilat | >1.5 cm | +ve | -ve | No | 70/33 | Flap recurrence + Ipsilat Parotid & Masticator Space |
| 7 | L | D (peripheral int. dose) | gingiva | T4aN1 | +ve | +ve Ipsilat | -ve | Bilat | ≤1.5 cm | +ve | +ve | No | 63/30 | Ipsilat Masticator Space |
| 8 | L | E (extraneous) | FOM | T1 N1 | -ve | +ve Bilat | -ve | Bilat | ≤1.5 cm | +ve | +ve | No | 60/30 | Mandibular gingiva |
| 9 | L | E (extraneous) | gingiva | T4aN1 | -ve | +ve Ipsilat | -ve | Ipsilat | ≤1.5 cm | -ve | -ve | No | 60/30 | Contralat mandibular gingiva |
| 10 | L | E (extraneous) | gingiva | T4aN2b | close | +ve Ipsilat | -ve | Ipsilat | ≤1.5 cm | +ve | -ve | C | 60/30 | Ipsilat masticator space |
| 11 | L | E (extraneous) | Buccal | yT2yN0 | -ve | -ve Ipsilat | -ve | Ipsilat | >1.5 cm | -ve | -ve | I + C | 60/30 | Ipsilat perineural spread along V2&V3 |
| 12 | LR | C (central int. dose) | tongue | T1 N1 | -ve | +ve Ipsilat | +ve | Bilat | ≤1.5 cm | -ve | -ve | C | 60/30 | FOM&Contralat level IIa |
| 13 | LR | C (central low dose) | tongue | T2 N0 | -ve | -ve Ipsilat | -ve | Bilat | ≤1.5 cm | -ve | +ve | C | 64/30 | Contralat tongue&level II |
| 14 | R | C (central low dose) | Hard palate | T3 N0 | -ve | -ve Ipsilat | -ve | Bilat | ≤1.5 cm | -ve | -ve | No | 60/30 | Contralat level IIa |
| 15 | R | C (central low dose) | gingiva | T4aNx | -ve | No dissection | N/A | Ipsilat | ≤1.5 cm | -ve | -ve | No | 64/32 | Ipsilat level Ib |
| 16 | R | C (central int. dose) | RMT | T2 N1 | -ve | +ve Ipsilat | -ve | Ipsilat | ≤1.5 cm | -ve | -ve | No | 60/30 | Ipsilat level Ib |
| 17 | R | C (central low dose) | tongue | T2 N1 | -ve | +ve Ipsilat | -ve | Bilat | ≤1.5 cm | -ve | -ve | No | 60/30 | Contralat level Ib |
| 18 | R | C (central int. dose) | tongue | T1 N1 | -ve | +ve Ipsilat | -ve | Bilat | ≤1.5 cm | -ve | -ve | No | 56/28 | Level Ia |
| 19 | R | Aa | tongue | T3N2b | -ve | +ve Ipsilat | +ve | Bilat | >1.5 cm | +ve | +ve | C | 60/30 | Ipsilat level III (A) Contralat level IIa (C) |
| 20 | R | Aa | RMT | T4aN2b | close | +ve Ipsilat | -ve | Bilat | ≤1.5 cm | -ve | U/S | C | 60/30 | Ipsilat level IIb (A) Ipsilat retropharyngeal node (D) |
| 21 | R | E (extraneous) | Buccal | yT3yN0 | close | -ve Ipsilat | -ve | Ipsilat | ≤1.5 cm | +ve | -ve | I | 60/30 | Contralat Pterygoid plates& maxilla |
| 22 | R | E (extraneous) | Buccal | T2N2b | close | +ve Ipsilat | -ve | Ipsilat | ≤1.5 cm | -ve | +ve | No | 60/30 | Ipsilat parotid node |
| 23 | R | E (extraneous) | Buccal | T2N2b | -ve | +ve Ipsilat | +ve | Ipsilat | ≤1.5 cm | -ve | -ve | C | 60/30 | Ipsilat parotid node |
| 24 | R | E (extraneous) | Buccal | T1N2b | close | +ve Ipsilat | +ve | Ipsilat | U/S | -ve | U/S | C | 63/30 | Contralat levels II, III, IV |
| 25 | R | E (extraneous) | gingiva | T2Nx | +ve | No dissection | N/A | Ipsilat | ≤1.5 cm | -ve | U/S | No | 65/30 | Contralat level II |
| 26 | R | G (low neck) | tongue | T1N2b | -ve | +ve Ipsilat | -ve | Bilat | ≤1.5 cm | +ve | +ve | No | 60/30 | contralat levels III, IV |
| 27 | R | G (low neck) | gingiva | yT4ayN0 | close | -ve Ipsilat | -ve | Ipsilat | >1.5 cm | +ve | U/S | I | 60/30 | Ipsilat level VIb |
aIndicates type A failure with multifocal recurrence that includes non-type A lesions as well. bThis patient had received only 6 fractions and failed to appear for the remainder of her treatments. Abbreviations. ECE extracapsular extension, DOI depth of invasion, PNI perineural invasion, LVI lymphovascular invasion, L local, R regional, LR locoregional, FOM floor of mouth, RMT retromolar trigone, −ve negative, +ve positive, Ipsilat ipsilateral, Contralat contralateral, Bilat bilateral, U/S unspecified, I induction chemotherapy, C concurrent chemotherapy, I + C induction followed by concurrent chemotherapy, No no chemotherapy