Fig. 1.

Recruitment of patients into the study. All patients admitted to the ICU in the three participating centers from 24 February 2014 until 17 December 2014, in whom blood glucose control needed to be initiated, were screened for eligibility. This resulted in 1550 patients who were randomized and analyzed (923 patients after cardiac surgery and 627 patients for other reasons as predefined). All patients were included in the primary analysis. LOGIC-C patients randomized to algorithm-guided blood glucose control, Nurse-C patients randomized to blood glucose control by trained nurses