Table 2.
Blood glucose control in the two randomized groups
| Nurse-C | LOGIC-C | P value | |||
|---|---|---|---|---|---|
| 95% CI | 95% CI | ||||
| Patients | 773 | 777 | |||
| Study period, median (IQR), days | 2 (2–4) | 2 (2–4)) | 0.7 | ||
| Efficacy | |||||
| Glycemic penalty index (GPI), median (IQR) | 17.1 (10.6–26.2) | 16.3–18.1 | 10.8 (6.2–16.1) | 10.0–11.5 | <0.001 |
| Blood glucose, mean (SD), mg/dL | 119 (21) | 118–121 | 111 (15) | 110–112 | <0.001 |
| Minimum blood glucose, mg/dL | 21 | 26 | |||
| Maximum blood glucose, mg/dL | 428 | 511 | |||
| Hyperglycemic index, median (IQR), mg/dL | 8.3 (3.4–16.3) | 7.5–8.8 | 3.5 (1.4–7.0) | 3.1–4.0 | <0.001 |
| Time-in-target range, median (IQR), percentage | 47.1 (28.1–65.0) | 45.7–49.3 | 67.0 (52.1–80.1) | 65.4–68.6 | <0.001 |
| Time to reach target range, median (IQR), h | 3.6 (0–9.3) | 3.2–4.3 | 2.2 (0–5.1) | 1.8–2.5 | <0.001 |
| Mean of maximum delta glycemia per day, median (IQR), mg/dL | 36 (27–52) | 35–38 | 34 (24–46) | 32–36 | <0.001 |
| Safety | |||||
| Hypoglycemia, proportion of patients | |||||
| <70 mg/dL, n (%) | 173 (22.4) | 151–196 | 149 (19.2) | 128 –171 | 0.1 |
| <60 mg/dL, n (%) | 78 (10.1) | 62–95 | 58 (7.5) | 44–73 | 0.07 |
| <40 mg/dL, n (%) | 9 (1.2) | 4–15 | 7 (0.9) | 2–13 | 0.6 |
| Hypoglycemia, proportion of samples | |||||
| <70 mg/dL, n (%) | 346 (1.8) | 311–382 | 342 (1.5) | 306–379 | 0.02 |
| <60 mg/dL, n (%) | 123 (0.7) | 102–145 | 105 (0.5) | 85–125 | 0.02 |
| <40 mg/dL, n (%) | 9 (0.05) | 4–15 | 9 (0.04) | 4–15 | 0.9 |
| Workload | |||||
| Sampling interval, mean (SD), h | 3.0 (0.8) | 2.9–3.0 | 2.3 (0.5) | 2.3–2.3 | <0.001 |
Data are mean (SD), median (IQR) or n (%). LOGIC-C patients randomized to algorithm-guided blood glucose control, Nurse-C patients randomized to blood glucose control by trained nurses