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. Author manuscript; available in PMC: 2017 Aug 15.
Published in final edited form as: Curr Opin Neurobiol. 2017 May 31;45:139–147. doi: 10.1016/j.conb.2017.05.019

Figure 3. The tripartite rule governs NMDAR-MAGUK supercomplex assembly.

Figure 3

(a) The tripartite rule describes the genetic requirement of three proteins that are essential for the assembly of NMDA-MAGUK synaptic supercomplexes in vivo. Schematic of NMDA receptor subunits (GluN1, GluN2, GluN3) in membrane showing the cytoplasmic tail of GluN2B interacts with PSD95 and PSD93. The assembly of NMDAR-MAGUK supercomplexes does not depend on the ESDV C-terminal PDZ binding site.

(b) Schematic showing how subunits of NMDA receptors assemble into three receptor complex subtypes and that only those that contain GluN2B can assemble into supercomplexes because of the tripartite rule.