Figure 5.

Brief overview of the tryptophan metabolic pathway with box plots included showing metabolites detected here and significantly altered by culture with inflammatory cytokines (blue rectangles). Metabolites significantly increased are shown in bold red, those significantly decreased in bold green color; the notation of the box plots is the same as used before in Figure 2 or Figure 3. The large changes in kynurenine and kynurenate are associated with significant increases in tryptophan intermediates 3-indoxyl sulfate and indolelactate as well as with concomitant loss of several nicotinamide intermediates suggesting that inflammatory conditions perturb tryptophan metabolism to favor the indole and kynurenine axes.