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. Author manuscript; available in PMC: 2017 Aug 15.
Published in final edited form as: Sci Signal. 2017 May 2;10(477):eaai8133. doi: 10.1126/scisignal.aai8133

Fig. 5. Administration of LIMK-i ameliorates neuromorphological and behavioral abnormalities in mouse model of FXS.

Fig. 5

(A and B) The FMR1-KO mice or WT littermates received vehicle (DMSO) alone (mock) or LIMK-i and were subjected to the rOFT at 3 to 3.5 months of age. The number of total activities (A) was counted during six sessions spanning 16 days (#1 and #2 on day 1, #3 and #4 on day 2, and #5 and #6 on day 16). (B) The total activities (left) and rearing behavior (right) during the first two and the last two sessions (sessions #1, #2, #5, and #6) were computed, and the averages per session are indicated. Data are means ± SEM.*P<0.05and **P<0.01, by ANOVA with posthoc Tukey’s test. n=9micefortheFMR1−/−/mock group. n = 11 for FMR1−/−/+LIMK-i. n = 10 for WT/mock. n = 7 for WT/+LIMK-i.