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. Author manuscript; available in PMC: 2018 Jul 6.
Published in final edited form as: ChemMedChem. 2017 Jun 12;12(13):1033–1044. doi: 10.1002/cmdc.201700196

Figure 2.

Figure 2

Modelling of selected AA5 derivatives in the ubiquinone binding site of porcine heart mitochondria complex II (PDB ID: 3AEE). A) Hypothetical binding interactions of CII inhibitor 16c. B) Overlay of AA5 (7) (turquoise) and 16c (gold) in active site of porcine heart mitochondria complex II. C) Hypothetical binding interactions of inactive compound 18. D) Hypothetical binding interactions of inactive compound 24 (gold), overlayed with AA5 (7) (turquoise). Red;oxygen, blue; nitrogen, white; hydrogen, gold; carbon. Green dotted lines represent hydrogen bond (greater opacity represents stronger bond).