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Complex II inhibitors with greater potency convey greater cytotoxicity. A) Dose-response curve of the effect of complex II inhibitor 16k on percentage cell viability of 22Rv1 prostate cancer cells. B) Dose-response curve of effect of complex II inhibitor 16k on the percentage cell viability of low tumorigenic HEK293 cells. Cell viability measured after 48-hour incubation of compound. Values are the mean ± S.D. of triplicate experiments.
