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Selectivity of compounds 16c, 16k and AA5 for inhibition of mitochondrial complex II over complex I.
| Compound | Complex II IC50 (nM) | Complex I IC50 (nM) | Selectivity Ratio (CII:CI) |
|---|---|---|---|
| 16c | 64 ± 4.3 | >10,000 | >156 |
| 16k | 3.3 ± 2.4 | >10,000 | >3030 |
| 7 (AA5) | 3.3 ± 2.0 | >10,000 | >3030 |
