Table 1.
Immuno-phenotype | Cytogenetic abnormality | Fusion gene | N | Median WBC at diagnosis, × 10^9/L (range) | Median age at diagnosis, years (range) |
---|---|---|---|---|---|
T-ALL | Various | 18 | 173.5 (1–588) | 11.9 (1.9–16.8) | |
BCP-ALL | HeH | – | 42 | 9.6 (0.8–124) | 3.6 (1.0–17.74 |
t(12;21) | ETV6-RUNX1 | 18 | 6.5 (1.1–95) | 4.9 (2.2–12.7) | |
11q23/MLL | MLL-r | 7 | 193 (1.8–744) | 0.6 (0.5–1.7) | |
t(9;22) | BCR-ABL1 | 6 | 88.3 (14.1–180) | 12.1 (9.3–13.5) | |
dic(9;20) | – | 1 | 41.8 (41.8–41.8) | 4.4 (4.4–4.4) | |
Various (BCP-ALL “other”)a | – | 42 | 7.9 (0–213) | 8.8 (1.4–17.7) | |
Total | 134 |
aBCP-ALL samples negative for targeted assays for known ALL cytogenetic aberrations with either non-recurrent aberrations, normal karyotypes, or no results available from cytogenetic analysis
WBC white blood cell count at diagnosis, MLL-r rearrangements involving the KMT2A (MLL) gene