Table 2.
Genetic alterations in patients with DUX4-IGH and ZNF384 rearrangements
| Fusion gene | Sample | Mutated ALL driver genesa | Copy number alterations |
|---|---|---|---|
| DUX4-IGH fusion gene | |||
| DUX4-IGH | ALL_176 | na | ERG deletion |
| DUX4-IGH | ALL_218 | na | Inconclusive |
| DUX4-IGH | ALL_312 | NRAS (p.G12D) | ERG deletion |
| DUX4-IGH | ALL_371 | NRAS (p.G12D) | ERG deletion |
| DUX4-IGH | ALL_390 | na | ERG deletion |
| DUX4-IGH | ALL_392 | na | ERG deletion |
| DUX4-IGH | ALL_501 | NRAS (p.G12S), KMT2D (p.H3883fs) | ERG deletion |
| DUX4-IGH | ALL_546 | NRAS (p.G12S) | ERG deletion |
| DUX4-chr8q24.21-IGH | ALL_205 | NRAS (p.G12D) | Inconclusive |
| ZNF384-rearranged fusion genes | |||
| TCF3-ZNF384 | ALL_604 | PTPN11 (p.E76Q) | chr7q deletion |
| TCF3-ZNF384 | ALL_622 | PTPN11 (p.T73I) | chr7q deletion |
| TAF15-ZNF384, ZNF384-TAF15 | ALL_8 | NRAS (p.Q61H) | – |
| EP300-ZNF384, ZNF384-EP300 | ALL_52 | na | – |
| EP300-ZNF384, ZNF384-EP300 | ALL_613 | na | – |
| EP300-ZNF384 | ALL_693 | na | – |
| ATP5C1-ZNF384 | ALL_257 | CREBBP (p.R1408C) | – |
aKnown ALL driver genes are reported in this table
na no targeted sequencing data available