Table 6.

In vitro RLMs metabolites of compound 8c

Compound	Compound/metabolite	Metabolic reaction	Monoisotopic mass (m/z)	Product ion (m/z)	Retention time (min)
8c	8c	–	414	386, 236, 234, 91	36.40
	8c Reduced	Reduction	416	388, 234, 91	36.35
	8c Reduced isomer	Reduction and isomerization	416	388, 234, 91	43.82
	8c Hydroxylated	Arom hydroxylation	430	234, 181	31.62
	8c Hydroxylated isomer 1	Arom hydroxylation and isomerization	430	412, 233, 107	32.30
	8c Hydroxylated isomer 2	Arom hydroxylation and isomerization	430	412, 250, 233, 107	38.96
	8c Hydroxylated isomer 3	Arom hydroxylation and isomerization	430	412, 233, 107	40.34
	8c Oxygenated	oxidation	428	322, 107, 79	27.25
	8c Oxygenated isomer 1	oxidation and isomerization	428	322, 107, 79	25.70
	8c Oxygenated isomer 2	oxidation and isomerization	428	105, 77	40.35
	8c Oxygenated isomer 3	oxidation and isomerization	428	179, 105, 77	44.24

Abbreviations: RLM, rat liver microsome; Arom, aromatic.