Table 4.

Multivariable-Adjusted Association of Diastolic Flow Velocity with Vascular Function Measures by Flow Reversal Status

	Flow Reversal		No Flow Reversal
	Est. β* (SE)	P	Est. β (SE)	P	Δβ (SE)†	P‡
Flow-mediated dilation, %	0.23 (0.04)	<0.0001	0.13 (0.01)	<0.0001	−0.10 (0.04)	0.04
Hyperemic flow velocity, cm/s	1.87 (0.23)	<0.0001	1.27 (0.08)	<0.0001	−0.60 (0.26)	0.02
Carotid femoral PWV §, m/s	−0.26 (0.02)	<0.0001	−0.02 (0.02)	0.004	0.24 (0.02)	<0.0001
Carotid radial PWV, m/s	0.14 (0.02)	<0.0001	−0.01 (0.01)	0.62	−0.13 (0.02)	<0.0001
Log baseline FVR (resting), (dyne · s−1 · cm−5)	−0.15 (0.01)	<0.0001	−0.12 (0.01)	<0.0001	0.03 (0.01)	<0.0001

Multivariable model adjusted for age, sex, cohort, mean arterial pressure, heart rate, body mass index, total/hdl cholesterol ratio, triglycerides, glucose, diabetes, current smoking, hypertension treatment, lowering lipid treatment, hormone replacement therapy, walk test (before), prevalent CVD.

^*β-represents the slopes of outcome variable versus diastolic flow velocity.

^†Difference in β estimates comparing flow reversal to no flow reversal (Δβ = β (no flow) − β (flow).

^‡For comparison of β for the association of diastolic flow velocity with vascular measures for flow reversal compared to no flow reversal, from test of Ho: Δβ = 0.

^§PWV denotes pulse wave velocity