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Proteasomal degradation pathway. Cos-7 cells transfected with 4 μg of S492F, ΔI507, or R560T were treated for 16 h with incremental doses of MG-132, a nonspecific proteasome inhibitor. Immunoblots and protein quantification of CFTR in A) S492F, B) ΔI507, and C) R560T (ANOVA, n = 3). Data were normalized to 0 μm (control); vs. 0 μm: *P < 0.05, **P < 0.01, ***P < 0.001. Ezrin (Ez) was used as a loading control.
