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The combination of correctors C18 and C4 rescues CFTR in CFTR constructs bearing mutations in NBD1. Cos-7 cells transfected with 4 μg of A455E, S492F, ΔI507, or R560T were treated for 16 h with incremental doses of C18+C4. Immunoblots and protein quantification of CFTR in A) A455E, B) S492F, C) ΔI507, and D) R560T (ANOVA, n = 4). Data were normalized to 0 μm (control); vs. 0 μm: *P < 0.05, **P < 0.01; vs. 10 μm: #P < 0.05. Ezrin (Ez) was used as a loading control.
