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. 2005 Mar 3;5:2. doi: 10.1186/1472-6904-5-2

Table 3.

Individual and mean pharmacokinetic parameters of genistein following a single dose of orally administered soy beverage (B) and soy extract capsules (C).

Subj No. Cmax (ng/ml) Cmax/Dose1 AUC0–32 (ng.h/ml) AUC0–32/Dose1 AUC0-∝ (ng.h/ml) AUC0-∝/Dose1 Tmax (h) t1/2 (h)

B C B C B C B C B C B C B C B C
1 90.41 151.49 8.60 6.71 954.82 1950.40 90.85 86.42 1040.69 2248.09 99.02 99.61 6 6 8.46 9.92
2 68.08 124.90 6.48 5.53 693.31 1821.17 65.97 80.69 739.89 1941.50 70.40 86.02 1 8 7.62 7.42
3 149.53 301.34 14.23 13.35 1801.34 4392.34 171.39 194.61 1989.66 5048.92 189.31 223.70 8 8 8.25 9.37
4 212.94 516.77 20.26 22.90 1979.53 5541.88 188.35 245.54 2140.25 6175.55 203.64 273.62 6 6 8.10 8.93
5 96.95 220.38 9.22 9.76 1281.58 2478.42 121.94 109.81 1423.11 3072.33 135.41 136.12 8 10 9.73 12.40
6 96.57 301.62 9.19 13.36 1277.75 2776.28 121.57 123.01 1483.87 2972.50 141.19 131.70 10 6 10.10 7.74
7 223.77 371.31 21.29 16.45 3184.25 5260.83 302.97 233.09 4022.02 6003.94 382.69 266.01 4 8 12.60 9.58
8 110.60 193.01 10.52 8.55 948.75 2217.44 90.27 98.25 998.31 2370.24 94.99 105.02 6 6 5.07 8.41
9 54.86 183.88 5.22 8.15 425.80 1481.47 40.51 65.64 527.69 1500.60 50.21 66.49 4 6 4.41 4.80
10 69.95 214.54 6.66 9.51 773.90 1856.73 73.63 82.27 789.07 1940.05 75.08 85.96 6 6 5.34 6.63
11 105.13 217.57 10.00 9.64 1128.81 3121.71 107.40 138.31 1177.74 3208.73 112.06 142.17 6 8 6.32 5.27
12 117.61 345.31 11.19 15.30 871.60 2591.36 82.93 114.81 914.46 2631.99 87.01 116.61 4 6 5.35 5.05

Mean 116.37 261.84ND 11.07 11.60 1276.79 2957.50ND 121.48 131.04 1437.23 3259.54ND 136.75 144.42 5.75 7.00 7.61 7.96

SD 53.80 110.68 5.12 4.90 746.04 1372.13 70.98 60.79 949.02 1599.34 90.30 70.86 2.34 1.35 2.44 2.28

1Pharmacokinetic parameters adjusted for oral administered dose. ND = statistical analysis was not performed due to differences in oral administered doses between both preparations.